関連する実験動画

Updated: May 5, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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免疫ペプチドミクスを用いたエピトープマッピングは,AAV9カプシドの新規の免疫優位性CD8T細胞エピトープを明らかにする

Akhila Balasubramanian1, Marek Prachar2, Birgit Klaproth2

  • 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States.

Frontiers in immunology
|August 27, 2025
PubMed
まとめ

この研究では,MHC関連ペプチドプロテオミクス (MAPPs) によって特定された自然に存在するアデノ関連ウイルス (AAV) カプシドペプチドが,従来の重複ペプチドと比較して異なるCD8T細胞応答を誘発し,AAV遺伝子療法の安全性を向上させるための新しいエピトープを特定することが明らかになりました.

キーワード:
AAV9 についてCD8 T細胞HLAクラスIカプシドエピトープ免疫監視免疫ペプチドミクス

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