新生児の骨代謝に対するCOVID-19に関連する行動制限の長期的影響:遡及的研究
Tatenobu Goto1, Ayako Uemura1, Hiroto Maeda1
1Division of Pediatrics, Yokkaichi Municipal Hospital, Yokkaichi, JPN.
Cureus
|August 27, 2025
まとめ
COVID-19 パンデミックは新生児の骨代謝を変化させ,リン酸の持続的な増加とマグネシウムの減少を引き起こしました. 継続的なモニタリングは 乳児の長期的な健康に不可欠です
科学分野:
- 新生児医学
- 生物化学
- 公衆衛生
背景:
- COVID-19 パンデミックに起因する生活習慣の変化は,母親と新生児の健康に影響を与える可能性があります.
- 新生児の骨代謝は環境や行動要因に敏感です
研究 の 目的:
- 新生児の骨代謝の生化学的マーカーのパンデミック関連の制限の影響を評価する.
- 新生児のカルシウム,リン酸,マグネシウム,無傷の副甲状腺ホルモン (iPTH),およびアルカリ性ファスファターゼ (ALP) のレベルを,流行前の,流行後の期間で比較する.
主な方法:
- 日本のNICUで964人の新生児を対象とした遡及コホート研究 (2018年−2024年).
- COVID-19前 (2018-2020),COVID-19パンデミック (2020-2022),およびCOVID-19後の (2022-2024) グループに分類する.
- 生後1日に測定された血清の生化学パラメータの統計的比較
主要な成果:
- 妊娠年齢や出生体重の有意な差はありません.
- COVID-19前期からCOVID-19後の期間の血清リン酸濃度の大幅な段階的な増加 (p<0. 01).
- COVID-19後期における血清マグネシウム濃度の有意な低下 (p<0. 01);カルシウム,IPTH,ALPの変化はありません.
結論:
- パンデミックに関連した生活習慣の変化は,新生児のリン酸とマグネシウムの代謝に重大な持続的な変化をもたらしました.
- これらの代謝の変化は,継続的な監視と介入戦略の必要性を強調しています.
- 発見は新生児の骨代謝が 外部要因に脆弱であることを強調しています
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