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外周動脈疾患患者のベートルジュースの有効性: 系統的レビュー
Carlos A Umaña Mejia1, Yolanda García Aguilar2, Yolik N Carracedo González3
1General Medicine, Universidad Autonoma De Guadalajara, Guadalajara, MEX.
Cureus
|August 27, 2025
まとめ
周周動脈疾患 (PAD) の患者の運動能力を改善し,血圧を下げる. しかし,現在の証拠は小規模な研究によって制限されており,確認のためにより大きな試験が必要である.
科学分野:
- 心血管医学
- 栄養学
- 運動 生理学
背景:
- 末動脈疾患 (PAD) は動脈硬化症の一般的な合併症で,足の痛みや運動能力の低下を引き起こします.
- 窒素酸化物 (NO) は血管の健康に不可欠であり,ビートジュース (BRJ) には窒素酸塩が豊富で,NOの前駆体となる可能性があります.
研究 の 目的:
- 安定したPADの成人のBRJの効果に関するランダム化対照試験 (RCT) を体系的にレビューする.
- BRJの運動能力 (クラディケーションの発生と歩行のピーク時間) と血圧への影響を評価する.
主な方法:
- PRISMA 2020のガイドラインに従い,PubMedとScienceDirectで検索する
- PADと断続的なクラディケーションが確認された5つのRCT (64人の患者) を含む.
- クラウディケーション発症時間 (COT),ピーク歩行時間 (PWT),血圧の変化の評価;バイアスのリスクの評価.
主要な成果:
- 2つの研究ではCOTとPWTの有意な改善が見られたが,他の研究では両群の有意な変化や改善は見られなかった.
- 3つの研究では,シストリック血圧とダイアストリック血圧の低下が観察され,2つの研究では,血清ナイトレート/ ナイトライト濃度の上昇が報告されました.
- 副作用は報告されていません.
結論:
- 予備的な証拠によると,BRJは運動能力を高め,血圧を低下させることで,PAD患者に利益をもたらす可能性がある.
- 発見は,サンプルサイズが小さいこと,試験設計の異質性,投与量,期間,および中等から高いバイアスのリスクによって制限されています.
- PADの管理におけるBRJの臨床的有用性を確認するために,標準化されたプロトコルを持つより大規模で長期的なRCTが必要である.
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