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KEYNOTE-522: 症例報告の後に改善した三重陰性転移性乳がん

Edoardo G Frezza1, Gayatri D Nimmagadda2, Olutayo Sogunro3

  • 1Medicine, Trinity School of Medicine, Baltimore, USA.

Cureus
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PubMed
まとめ

メタプラスティック乳がん (MpBC) は,希少で攻撃的なサブタイプで,しばしば治療に抵抗します. トリプルネガティブのMpBC症例は,化学療法とペンブロリズマブ免疫療法に完全な反応を示し,改善への希望を示した.

キーワード:
乳がん心臓サルコイドーシス (cs)キーノート 522転移性転移性乳がんトリプルネガティブ乳がん

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...