肥満に関連する代謝併発症に関連する表遺伝的変化

Ionel Sandovici^1,2,3, Tiago Morais^4,5, Miguel Constância^1,2,3

¹Department of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0SW, UK.

Journal of the Endocrine Society

|August 27, 2025

まとめ

食生活や行動に起因するエピジェネティックの変化は肥満や関連する代謝疾患に大きく寄与しますこれらの可逆的な変化は肥満の合併症に対する治療の標的となる可能性があります

科学分野:

内分泌学
遺伝学
メタボリズム

背景:

肥満は遺伝的,ホルモン的,食事的,行動的要因に起因しエネルギー不均衡,脂肪の蓄積,炎症,インスリン抵抗性の原因となります
DNAメチル化とヒストンの改変を含む表遺伝的メカニズムは,肥満の発達と伝播における役割としてますます認識されています.

研究の目的:

肥満における細胞代謝と表遺伝子の相互作用を検討する.
肥満と関連する代謝疾患の表遺伝的変異を強調する
エピジェネティック・モディフィケーションの治療の可能性を探るため

主な方法:

肥満における表遺伝的変化に関する最近のヒトとマウスの研究のレビュー.
代謝器官と外周血液における表遺伝的変化の分析
エピジェネティクスと代謝機能障害を結びつけるメカニズムの検討

主要な成果:

エピジェネティックの変化は肥満の病因,進行,世代間のリスクと関連しています.
インスリン抵抗性や2型糖尿病のような併発性疾患を持つ肥満と代謝的に健康な肥満を区別する特定の表遺伝的変異がある.
外周血液の表遺伝子バイオマーカーは,肥満に関連する代謝併発症を予測することができる.

結論:

エピジェネティックメカニズムは肥満とその代謝合併症に重要な役割を果たします
外周血液中の表遺伝子バイオマーカーは,病原性および病原性予測の洞察を提供します.
肥満および関連疾患の治療に役立つ可能性を示しています.

キーワード:

DNAメチル化環境要因エピジェネティクス肥満肥満併発症

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