タンパク質のみおよび炭水化物のみの高摂取量の血代謝産物およびホルモンの影響,窒素排出に加えて
Matthieu Clauss1, Claire Puissant1, Nasser Ezzatkhah Bastani2
1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Frontiers in endocrinology
|August 27, 2025
まとめ
血清アミノ酸とGLP-1を増加させ,炭水化物の摂取はインスリンとGIPを増加させた. タンパク質の摂取は尿中の窒素分泌量の増加につながり,タンパク質の分解が増加したことを示しています.
科学分野:
- メタボリックとホルモンの反応
- 栄養科学と運動生理学
背景:
- 高いタンパク質摂取のホルモンおよび代謝効果については,さらなる調査が必要である.
- これらの反応を理解することは 栄養戦略の最適化に不可欠です
研究 の 目的:
- 代謝とホルモンの反応を同カロリー乳清タンパク質と炭水化物の摂取と比較する.
- タンパク質の分解のマーカーとして尿中の窒素分泌を評価する.
主な方法:
- ダブルブラインド ランダム化 クロスオーバー 14人の健康な参加者
- 乳清タンパク質 (PRO) や炭水化物飲料 (CHO) の摂取
- 血液サンプルと24時間の尿サンプルを採取して分析する.
主要な成果:
- 炭水化物摂取は血のグルコースとインスリンを増加させ,タンパク質摂取は血のアミノ酸とGLP-1を増加させた.
- PROとCHOの両方がインスリン,GLP-1,GIPを増加させたが,パターンは異なった.
- 尿中の窒素分泌量は,PROを摂取した後に,特に摂取後2~8時間の間に,著しく増加した.
結論:
- タンパク質誘発のインスリン反応は,アミノ酸とGLP-1によって,グルコースとは無関係に媒介されます.
- GLP-1の反応はタンパク質で,GIPの反応は炭水化物でより大きい.
- タンパク質の摂取は尿中の窒素分泌を増加させ,タンパク質の分解が強くなることを示唆する.
関連する概念動画
Overview of Protein Metabolism
1.8K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.8K
Proteins: Dietary Sources and Requirements
622
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
622
Chronic Kidney Disease III: Interprofessional Care
78
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
78
Regulation of Food Intake
370
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
370
Metabolic States of the Body: The Absorptive State
791
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
791
Overview of Nitrogen Metabolism
8.5K
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of ammonia, ammonium ions, nitrate, nitrite, or nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
8.5K


