関連する実験動画

Updated: Sep 10, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

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遺伝子ネットワークの構造とダイナミクス:単純なネガティブなフィードバックループの識別

Theodore J Perkins1, Roderick Edwards2, Leon Glass3

  • 1Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Interface focus
|August 27, 2025
PubMed
まとめ

研究者は観察された細胞動力学から遺伝子相互作用を識別する方法を開発した. このアプローチでは,遺伝子のネットワークモデル,特に単純なネガティブなフィードバックシステムを分析し,データパターンから相互作用を推論します.

キーワード:
ブール式スイッチングネットワーク遺伝子ネットワーク逆の問題非線形ダイナミクス

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Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
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Positive and Negative Feedback Loops

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Root Loci for Positive-Feedback Systems

The Hartley oscillator is a positive feedback system that sustains oscillations by feeding the output back to the input in phase, thereby reinforcing the signal. Positive feedback systems can be viewed as negative feedback systems with inverted feedback signals. In these systems, the root locus encompasses all points on the s-plane where the angle of the system transfer function equals 360 degrees.
The construction rules for the root locus in positive feedback systems are similar to those in...
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Feedback Loops01:01

Feedback Loops

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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
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