関連する実験動画

Updated: Sep 10, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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基底性乳がんにおける遺伝子メチル化-miRNA-転写因子フィード・フォワード・ループの表遺伝子制御ネットワークの識別

Larissa M Okano1, Alexandre L K de Azevedo2, Tamyres M Carvalho2

  • 1Research Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.

Cells
|August 27, 2025
PubMed
まとめ

この研究は,DNAメチル化とマイクロRNAを含む表遺伝的変化が,基礎性乳がん (BLBC) の複雑な規制ネットワークを作成する方法を示しています. これらの発見は,BLBCの進行の主要な原動力としてフィード・フォワード・ループ (FFL) を強調し,潜在的な治療目標を提供します.

キーワード:
DNAメチル化基礎性乳がんディスタルプローブ送料ループ遺伝子miRNA (ミラーナ)規制エピジェネティックネットワーク転写因子

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