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Updated: Sep 10, 2025

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
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Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

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中枢神経系の修復と再生のためのヒトのIPSC

Haiwei Zhang1, Hongxia Zhou1,2, Xugang Xia1,2

  • 1Center for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.

Cells
|August 27, 2025
PubMed
まとめ

遺伝子工学によるヒト誘発性多能幹細胞 (iPSC) は,普遍的な移植のために免疫拒絶を克服することができます. このレビューは,中枢神経系 (CNS) の治療における低免疫性 iPSC の戦略を調査します.

キーワード:
免疫拒絶症移植ユニバーサル 幹細胞

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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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