関連する実験動画

Updated: Sep 10, 2025

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
07:55

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

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ADGRE5の解読:タンパク質分裂と機械的な力が細胞信号を放つ方法

Ana L Moreno-Salinas1, Arturo Mancini2, Samya Aouad2,3

  • 1Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

Cells
|August 27, 2025
PubMed
まとめ

粘着Gタンパク質結合受容体ADGRE5 (CD97) のシグナリングは複雑である. この研究では,GPS割れ独立のメカニズムと,腫瘍学薬の開発に不可欠な機械的刺激を含む,新しい活性化経路が明らかになりました.

キーワード:
ADGRE5 についてBRET についてCD55 についてaGPCRs について偏ったシグナル機械的刺激

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Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell14:09

Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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