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アントロポメトリーとモロッコの女性の乳がんリスク:大規模な多中心的症例対照研究
Najia Mane1,2, Najoua Lamchabbek2,3, Siham Mrah4
1Laboratory of Epidemiology and Research in Health Sciences, Pharmacy and Dental Medicine, Faculty of Medicine, Sidi Mohamed Ben Abdallah University, Fez 30070, Morocco.
Current oncology (Toronto, Ont.)
|August 27, 2025
まとめ
腰と股関節の周長などの肥満指標は,閉経前と閉経後のモロッコの女性に乳がん (BC) のリスクを高めます. 体質指数 (BMI) と体重は,更年期状態に応じて,BCリスクと異なる関連性を示しています.
科学分野:
- 腫瘍学
- 流行病学
- 公衆衛生
背景:
- 肥満は閉経後の乳がん (BC) のリスク因子として知られています.
- 肥満と閉経前BCリスクの関連性は理解されていない.
- モロッコの人口,特に更年期状態に関するこの関係に関するデータは限られている.
研究 の 目的:
- モロッコの女性における様々な肥満指標と乳がん (BC) のリスクとの関連を調査する.
- 閉経前と閉経後の状態による潜在的差異的関係を調べる.
主な方法:
- モロッコで行われた多センター症例対照研究 (2019年12月 - 2023年8月).
- 1,400件の BC症例と1,400件の対照群を含む.
- 詳細なアンソポメトリック測定値と自己報告されたデータを人生の各段階にわたって収集し,無条件のロジスティック回帰を使用して分析します.
主要な成果:
- 腰周長 (WC) と股関節周長 (HC) の増加は,閉経前と閉経後の女性において,より高いBCリスクに関連していた.
- 現在の高体量指数 (BMI) (≥30 kg/ m2) は閉経後のBCリスクの増加と関連していました.
- 20歳と30歳の体重と若い成人のBMIは,両方のグループでBCリスク傾向が増加した. 20歳以降の体重増加は,閉経後の女性で逆の関連を示した.
結論:
- アントロポメトリック要因は,モロッコの女性における閉経前および閉経後の乳がんリスクとの様々な関連を示しています.
- 発見は,BCリスクに関連して,人生のさまざまな段階における肥満の重要性を強調しています.
- これらの関連性とその分子関連性を明らかにするために,さらなる大規模な前向きな研究が必要である.
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