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Updated: May 2, 2026

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
12:01

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Published on: May 30, 2015

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ヒトα-シヌクレイントランスジェニックマウスの核定位における行動変化の確立と特徴付け

Ziou Wang1, Mengchen Wei1, Shengtao Fan1

  • 1Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 935, Jiaoling Road, Kunming 650118, China.

Diseases (Basel, Switzerland)
|August 27, 2025
PubMed
まとめ

この研究では,核に局所化されたヒトアルファ-シヌクレイン (α-syn) を搭載したトランスジェニックマウスモデルを作成した. これらのマウスは神経炎症による早期運動欠陥を示し,後のストレス誘発のアポトーシスによる不安行動を示し,パーキンソン病の研究を支援しています.

キーワード:
不安のような行動人間のα-シヌクレイン運動障害核の位置づけトランスジェニックマウス

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