胃炎患者における老化と唾液機能低下に関連した口腔カンジダシス
Yeon-Hee Lee1,2, Solsol Seo1, Tae-Seok Kim1
1Department of Orofacial Pain and Oral Medicine, Kyung Hee University, Kyung Hee University Dental Hospital, #613 Hoegi-dong, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Journal of fungi (Basel, Switzerland)
|August 27, 2025
まとめ
唾液の流れの減少は,クセロストミアとして知られる状態で,口腔カンジダ症の重要な予測因子です. この真菌感染症は 刺激を受けていない唾液の流れの減少と 強く結びついています
科学分野:
- 口腔医学
- 感染症
背景:
- 口内炎は口腔粘膜の炎症を伴うもので,口腔カンジダは一般的な真菌感染症のサブタイプである.
- 唾液の流れの減少 (キセロストミア) は,口腔炎の患者で頻繁に観察され,真菌感染症に対する感受性を増加させる可能性があります.
研究 の 目的:
- 口内カンジダ症と唾液の流れの減少との関連を調査する.
- この集団における口腔カンジダシスの臨床的予測要因を特定する.
主な方法:
- 259人の口腔炎患者をCandida albicans培養物で検査した.
- 非刺激性唾液流量 (UFR) と刺激性唾液流量 (SFR) を測定し,キセロストミアを評価する.
- カンディダ陽性群とカンディダ陰性群の臨床特性比較
主要な成果:
- 口内カンジダ症は31. 3%の患者で診断された.
- カンジダ陽性患者は高齢で,UFRとSFRが著しく低下した.
- 縮小したUFRは口腔カンジドーシスの強い予測因子 (AUC=0. 658) であり,ゼロストミアは一般的な線形モデルにおける有意な予測因子であった.
結論:
- 経口カンジダは,老化よりも,口腔炎患者での唾液流量減少と強く関連しています.
- 減少したUFRは,特に高齢者の口腔カンジダ症を予測するための貴重な臨床指標です.
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