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Updated: Sep 10, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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ダサチニブは,SRC- MAPK経路の調節により,マクロファージにおけるベータコロナウイルスの複製を抑制し,炎症促進媒介体を弱くする

Ana Carolina Santos Ricoy1, Marina Pimenta Braga1, Thaís Targino Ferreira Lacerda1

  • 1Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Medical microbiology and immunology
|August 27, 2025
PubMed
まとめ

ダサチニブ (DASA) は,マクロファージにおけるSRCシグナル伝達を標的として,ベータコロナウイルスの複製と炎症を減少させます. この研究では,DASAがコロナウイルス感染症の潜在的補助療法であり,ウイルスの侵入と炎症経路に影響を与えることを示唆しています.

キーワード:
ダサチニブ (DASA)MAPK信号経路MHV-3ベータコロナウイルスマクロファージSrcファミリーキナーゼ

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