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Updated: Sep 10, 2025

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ミトコンドリアのROSは,動脈硬化におけるSTAT5信号による泡細胞形成を誘発する

Laura Boccuni1,2, Frieda Marka1, Manuel Salzmann3

  • 1Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.

Science advances
|August 27, 2025
PubMed
まとめ

酸化されたLDL (oxLDL) はミトコンドリアの超酸化物を増加させ,泡細胞の形成を促します. これはSTAT5を活性化し,代謝を変化させ,動脈硬化症の進行を促進します. STAT5を阻害すると 泡細胞の分化が妨げられます

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