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Updated: Sep 10, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

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推定PINK1/パーキン活性化剤は,細胞をミトコンドリアストレスに敏感にすることで,ミトファギーの値を下げます

William M Rosencrans1,2, Ryan W Lee1, Logan McGraw1

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Science advances
|August 27, 2025
PubMed
まとめ

パーキンソン病におけるミトファギーの強化を目的とした2つの化合物は,予期せぬ非標的効果を示した. これらのミトファジー活性化剤はミトコンドリアのストレスを引き起こし,細胞の生存能力に影響を与え,治療戦略の洞察を提供します.

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