ヒトのケラチノサイトにおけるPM10誘発酸化ストレスに対するイヌラ・ジャポニカの葉抽出物の保護効果
Yea Jung Choi1, So-Ri Son2, Sullim Lee3
1College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
Current issues in molecular biology
|August 27, 2025
まとめ
イヌラ・ジャポニカの葉のエキスは,酸化ストレスと炎症を軽減することによって,汚染による損傷から皮膚細胞を保護します. この天然の化合物は環境要因による皮膚疾患の治療に役立つ可能性がある.
科学分野:
- 皮膚科
- 酸化ストレスに関する研究
- 自然製品化学
背景:
- 粒子状物質 (PM10) への曝露は酸化ストレスと炎症によって皮膚損傷を引き起こす.
- ヒトのケラチノ細胞は 皮膚の環境ストレス要因の 重要な標的です
- 自然抽出物は,汚染による皮膚老化に対する保護効果を調査しています.
研究 の 目的:
- ヒトのケラチノサイトにおけるPM10誘発の酸化ストレスに対するイヌラ・ジャポニカの葉の抽出物の保護の可能性を調査する.
- 抽出物の保護効果の背後にある分子メカニズムを解明する.
- 抽出物の重要な化合物を特定し,その治療効果を明らかにする.
主な方法:
- 細胞活性の測定,反応性酸素種 (ROS) の測定
- 遺伝子とタンパク質発現分析 (qRT-PCR,ウエスタンブロット)
- UHPLC-MSプロファイリングとネットワーク薬理学分析
主要な成果:
- イヌラ・ジャポニカの抽出物は,PM10によるROSの生成と細胞損傷を著しく減少させた.
- 抽出物はロリクリンの発現を向上させることで 皮膚のバリア機能を回復させた.
- MAPK信号伝達経路を阻害し,主要なアポプトシスおよび炎症マーカー (Bax,p53,MMP- 9,COX- 2) を調節した.
結論:
- イヌラ・ジャポニカの葉の抽出物は,PM10による皮膚損傷に対する重要な保護効果を示しています.
- そのメカニズムは,酸化ストレスとケラチノ細胞の炎症を軽減することです.
- この抽出物は汚染による皮膚疾患の治療に 有望な候補である.
さらに関連する動画
10:00Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
Published on: December 11, 2020
2.6K
09:31Determining the Toxicity of UV Radiation and Chemicals on Primary and Immortalized Human Corneal Epithelial Cells
Published on: July 22, 2021
2.2K
関連する概念動画
Plant Hormones
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
Responses to Salt Stress
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Stress Concentrations
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller width...
Stress Concentrations
The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress concentration...
The stress concentration...
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
