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Updated: Sep 10, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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KRAS変異CRCの潜在的な戦略としてのPRMT5阻害:PRMT5-KRASクロストックの下流媒介

Mark Spivak1, Moshe Pahmer2, Dorna Delrahimnia3

  • 1College of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.

Current issues in molecular biology
|August 27, 2025
PubMed
まとめ

研究者らは,MYC,E2F1,EIF4Eを,タンパク質アルギニンメチルトランスファーゼ5 (PRMT5) と結腸直腸がん (CRC) のクロストークを媒介する重要なタンパク質として特定した. この発見は,KRAS変異性CRC,挑戦的ながんサブタイプに対する新たな治療標的を提示しています.

キーワード:
CRC についてE2F1 についてEIF4E についてKRAS についてMYC についてPRMT5 について

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