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Updated: Sep 10, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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癌細胞におけるTEAD·YAP1転写因子の小分子共性安定化および抑制

I-Ju Yeh1, Khuchtumur Bum-Erdene1, Mona K Ghozayel2

  • 1Department of Veterans Affairs, Richard L. Roudebush VA Medical Center, Indianapolis, Indiana 46202, United States.

ACS chemical biology
|August 27, 2025
PubMed
まとめ

新しい小さな分子は TEADタンパク質を安定させ,パルミタート結合を模倣します. これらの化合物は TEADとYAP1のタンパク質を意外に劣化させ,がん細胞の生存能力を阻害し,新しい治療戦略を提供する.

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All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System09:55

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