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Updated: Sep 10, 2025

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
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肝細胞におけるFXRを標的とする: 繊維分解を促進し,深静脈血栓形成のリスクを減らすための有望なアプローチ

Bolin Li1, Heze Fan1, Hao Wu2

  • 1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'An, China.

Blood
|August 27, 2025
PubMed
まとめ

肥満は,肝臓におけるプラズミノゲン活性化剤阻害剤1 (PAI-1) の増加により,深静脈血栓症 (DVT) のリスクを高めます. 肝細胞におけるFXRの活性化により,PAI-1が減少し,線維分解が改善され,DVTの負荷が低下する.

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