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Updated: Sep 10, 2025

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
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Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

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免疫刺激剤CELMoDの組み合わせは,多発性骨髄腫の高い負荷によって引き起こされるT細胞エンゲージャに対する抵抗を克服します

Erin W Meermeier1, Kirsten Pfeffer1, Caleb K Stein1

  • 1Mayo Clinic, Scottsdale, Arizona, United States.

Blood
|August 27, 2025
PubMed
まとめ

双特定T細胞誘導剤 (TCE) とイカロス分解剤とデキサメタゾンを併用することで,多発性骨髄腫 (MM) の耐性を克服する. この戦略は,シトカイン放出症候群 (CRS) のリスクが低下した高腫瘍負荷の環境において,T細胞の反応と生存を改善します.

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