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Updated: May 7, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
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物質Pは,リポポリサッカリド誘発の認知障害を,ラットで用量依存的に軽減する

Prasada Chowdari Gurram1, Suman Manandhar2, Sairaj Satarker2

  • 1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India; KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh 522302, India.

Neuropeptides
|August 27, 2025
PubMed
まとめ

物質P (SP) はアルツハイマー病 (AD) モデルに用量依存的な効果を示しています. 低用量SPは認知機能を改善し,神経炎症を軽減したが,高用量SPはこれらの欠陥を逆転させなかった.

キーワード:
アルツハイマー病リポポリサッカリド神経炎症ニューロキニン受容体物質-P

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