関連する実験動画

Updated: Sep 10, 2025

The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking
08:51

The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking

Published on: February 12, 2022

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BLOC-1とBORC:エンドリソーム動態の複合調節体

Raffaella De Pace1, Saikat Ghosh1, Chad D Williamson1

  • 1Division of Neuroscience and Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Cell chemical biology
|August 27, 2025
PubMed
まとめ

BLOC-1とBORCタンパク質複合体は,エンドリゾームの動きと融合を調節する. これらの複合体の変異は Hermansky-Pudlak症候群と神経発達障害を引き起こす.

キーワード:
ヘルマンスキ・プードラック症候群アクソンエンドソーム核融合リソソームメラノソームマイクロチューブル神経発達障害シナプスベシクル輸送

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In Vitro Polymerization of F-actin on Early Endosomes12:15

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
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The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
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The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
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