展開されたタンパク質応答転写因子XBP1は,粘液の障壁を強化することによって,死滅による大腸炎を抑制する

関連する実験動画

Updated: Sep 10, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Published on: December 16, 2021

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Göksu Gökberk Kaya1, Robin Schwarzer1, Marius Dannappel1

  • 1Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

Immunity
|August 27, 2025
PubMed
まとめ

X- ボックス結合タンパク質1 (XBP1) 欠乏症は,結腸死を引き起こす大腸炎を悪化させ,大腸の粘液障壁を損なう. これは,炎症性腸疾患 (IBD) の病原性におけるエンドプラズマの網膜ストレスと死滅の間の重要な交響点を強調しています.

キーワード:
FADD についてIRE1 についてXBP1 についてカスパース-8粘液層の障害炎症性腸疾患腸内皮質障壁ミュシン 2ネクロプトーシス解き放たれたタンパク質反応

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