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Updated: Sep 10, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

Published on: May 13, 2020

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小分子によるTMEM175の活性化に関する構造的洞察

Xuewu Zhu1, Meixuan Ping2, Heng Liu3

  • 1Zhongshan Institute for Drug Discovery, SIMM, Zhongshan 528400, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Neuron
|August 27, 2025
PubMed
まとめ

トランスメブランタンパク質175 (TMEM175) は,有毒なアルファシヌクレインをクリアすることによって,パーキンソン病 (PD) を治療することができる. この研究は,新しいPD治療法への道を開く,新しいアゴニストを持つTMEM175のオープン構造を明らかにしています.

キーワード:
パーキンソン病TMEM175 についてアゴニスト結合する場所リソソーム

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