Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Conformations of Butane02:20

Conformations of Butane

14.8K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
14.8K
Conformations of Ethane and Propane02:18

Conformations of Ethane and Propane

14.5K
In an organic molecule, free rotation about the carbon-carbon single bond results in energetically different conformers of the molecule. Due to this rotation, called the internal rotation, ethane has two major conformations — staggered and eclipsed.
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered...
14.5K
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

12.2K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
12.2K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

915
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
915
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.2K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.2K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

13.0K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
13.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The psychological process and support needs of HIV-positive individuals who disclose their status to sexual partners: a qualitative study.

Frontiers in public health·2026
Same author

Optimization strategies for crystal orientation in antimony-based chalcogenide thin-film solar cells.

Nano convergence·2026
Same author

Sweet artificial intelligence as digital catalysts in infectious diseases: Glycomics and glycoanalysis.

Biosensors & bioelectronics·2026
Same author

Molecular rotation and large polarization in charge-transfer ferroelectric cocrystals.

Nature chemistry·2026
Same author

The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation.

Molecular & cellular proteomics : MCP·2026
Same author

Case Report: A rare case of oesophageal cellulitis caused by <i>Klebsiella pneumoniae</i>: diagnosis, management, and literature review.

Frontiers in medicine·2026
Same journal

Electrical impedance spectroscopy of young and old mouse multiple tissues.

Biomedical physics & engineering express·2026
Same journal

MELF: A multi-view ensemble learning framework for normative resting state EEG signal quality assessment.

Biomedical physics & engineering express·2026
Same journal

Rhythm-adaptive signal processing for effective ECG and PPG-based authentication under dynamic physiological conditions.

Biomedical physics & engineering express·2026
Same journal

Influence of storage temperature and humidity on entrance window deformations of phantoms for a horizontal beam geometry.

Biomedical physics & engineering express·2026
Same journal

Metamaterial-loaded waveguide antenna with integrated gradient-index cooling lens for abdominal subcutaneous adipose ablation.

Biomedical physics & engineering express·2026
Same journal

Adaptive deformation decomposition network for unsupervised medical image registration.

Biomedical physics & engineering express·2026
関連記事をすべて見る

関連する実験動画

Updated: Sep 10, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

754

コンフォマー-BiLSTMモデルに基づく咳検出方法

Wenlong Xu1, Hangrui Zhang1, Chen Pan1

  • 1College of Information Engineering, China Jiliang University, Hangzhou, Zhejiang, People's Republic of China.

Biomedical physics & engineering express
|August 27, 2025
PubMed
まとめ
この要約は機械生成です。

この研究では,咳の音を正確に検出するためのハイブリッドコンフォマーと双方向の長期短期記憶 (BiLSTM) ネットワークを導入します. このモデルは,咳の出来事を正確に特定し,呼吸器疾患の分析を改善します.

キーワード:
コンフォーマー・ビートム・モデル咳を検出するディープラーニングマルチヘッドの注意残留接続

さらに関連する動画

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

753
Author Spotlight: Advancements in the Fabrication of Synthetic Vocal Fold Models for Phonetic and Robotic Applications
06:24

Author Spotlight: Advancements in the Fabrication of Synthetic Vocal Fold Models for Phonetic and Robotic Applications

Published on: January 5, 2024

975

関連する実験動画

Last Updated: Sep 10, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

754
Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

753
Author Spotlight: Advancements in the Fabrication of Synthetic Vocal Fold Models for Phonetic and Robotic Applications
06:24

Author Spotlight: Advancements in the Fabrication of Synthetic Vocal Fold Models for Phonetic and Robotic Applications

Published on: January 5, 2024

975

科学分野:

  • コンピュータ言語学
  • バイオメディカル信号処理
  • 医療のための機械学習

背景:

  • 咳の検出は呼吸器疾患の診断に不可欠です.
  • 手動での咳の音のセグメンテーションは時間のかかるもので,主観的です.
  • 現実世界での咳の記録は,環境とデバイスの多様性のために検出の課題を提示します.

研究 の 目的:

  • 咳の音の発生を自動で正確に検出する方法を開発する.
  • 咳の分析の効率と客観性を向上させる
  • 様々な現実の音声データから 咳を検出する難しさに対処するためです

主な方法:

  • コンフォマーと双方向の長期短期記憶 (BiLSTM) ネットワークを組み合わせたハイブリッドモデルが提案されました.
  • BiLSTMモデルは文脈的な情報を捕捉し,コンフォマーモデルは複数のヘッドの注意残留接続を使用して全局的な特徴を抽出しました.
  • このモデルは,一般に利用可能なVocalsoundデータセットで訓練され,検証され,1928年に注釈された咳の音を含む500のオーディオファイルで構成されています.

主要な成果:

  • ハイブリッドモデルは,注釈されたデータセットで97.22%の感度と97.08%の特異性を達成した.
  • 臨床データセットの評価では,このモデルは98. 45%の感度と92. 7%の特異性を示した.
  • 臨床データセットでは平均81. 12%のタイムオーバーラップ率が記録され,正確なイベントの局所化を示した.

結論:

  • 提案されているコンフォマー-BiLSTMハイブリッドモデルは 咳の音の自動検知に 堅牢で正確なソリューションを提供します.
  • このアプローチにより,呼吸器疾患の研究における咳の分析の効率と信頼性が著しく向上します.
  • 公的データセットと臨床データセットの両方において,このモデルの高い性能は,医療における実用的な応用の可能性を示唆しています.