関連する実験動画

Updated: Sep 10, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

肝胆がんに対する新たな標的と新薬

Stephen L Chan¹, Angela Lamarca², Chiun Hsu³

¹State Key Laboratory of Translational Oncology, Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Department of Clinical Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Journal of hepatology

|August 27, 2025

まとめ

肝胆がんの治療法が新しくなり免疫系や以前は薬が効かない標的を狙っています臨床試験では,新しい免疫療法,細胞療法,肝臓と胆管がんに対する抗体-薬剤結合剤を研究しています.

科学分野:

腫瘍学
免疫療法
薬物開発

背景:

肝胆がん (HCCとBTC) の治療は急速に進歩しています.
従来の治療法は免疫系を標的とした新しいアプローチと挑戦的な分子標的で補完されています

研究の目的:

肝胆がんの現在の治療戦略と新たな治療戦略の見直し
免疫療法細胞療法標的薬の開発の進歩を強調する

主な方法:

肝胆がんの治療における現在の研究と臨床試験のレビュー
新しい免疫チェックポイント阻害剤,細胞療法 (CAR-T,TILs),双特定抗体,抗体-薬物結合剤に焦点を当てます.
伝統的に薬効性のない標的に対する新しい標的とアプローチの探索

主要な成果:

薬物開発の2つの主要な方向性:免疫システムの調節と,新しい/薬効性のない標的をターゲットにする.
新興療法には,新種の免疫チェックポイント抗体,サイトカイン,CAR-T細胞,TILs,双特定T細胞誘導体,および抗体-薬物結合体が含まれます.
初期の臨床研究では,HCCとBTCにおける細胞療法が有望であることが示され,特定のBTC亜型に対する抗体-薬物結合体が開発されています.

結論:

治療の進歩により肝胆がんの治療パラダイムが変わりつつありサルコマトイド性HCCや併合性HCC-コレランジオカルシノーマなどの稀なサブタイプも含まれています
免疫チェックポイント阻害剤を含むこれらの新しい治療法は,希少な肝臓がんのサブタイプの可能性を示しており,臨床試験に含めることが必要である.

さらに関連する動画

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

関連する概念動画

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Targets for Drug Action: Overview

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...