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Updated: Sep 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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炎症によるアベマシクリブ誘発の皮膚反応

Tugce Boran1, Özce Pala Çamlı2, Mahmoud Abudayyak3

  • 1Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İstanbul University Cerrahpaşa, İstanbul, Türkiye.

Toxicology letters
|August 27, 2025
PubMed
まとめ

乳がん薬であるアベマシクリブは皮膚反応を引き起こす可能性があります. この研究では,低用量ではヒトの皮膚細胞の酸化性炎症によって細胞死亡が誘発され,高用量では効果がないことが示されました. 更に研究が必要である.

キーワード:
アベマシクリブ細胞毒性炎症キナーゼ阻害剤酸化ストレス

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