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Updated: Sep 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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マンギフェリンは,PI3K/ AKT/ mTORシグナル伝達を抑制することで,PKFB3を標的とし,膠芽細胞腫の進行を抑制する

Jiajie Xia1, Xiao Li2, Jun Yao3

  • 1Department of Neurosurgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.

Brain research bulletin
|August 27, 2025
PubMed
まとめ

マンギフェリンは天然の化合物で,PFKFB3酵素をターゲットにすることで,膠芽細胞腫 (GBM) の成長を効果的に抑制します. マンギフェリンは

キーワード:
グリオブラストーマグライコリシス抑制マンギフェリンPFKFB3 についてPI3K/Akt/mTOR経路について

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Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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