統合失調症または双極性障害の家族リスクの高い子供の性別皮質の脳の違い
Kathrine Skak Madsen1, William F C Baaré1, Enedino Hernandez-Torres1
1Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|August 27, 2025
まとめ
統合失調症 (SZ) または双極性障害 (BP) の家族高リスク (FHR) の子供は,性別の脳の違いを示します. FHR-SZの男性では 脳の容量が小さく,FHR-BPの女性では 脳の容量が大きかった.
科学分野:
- 神経科学
- 精神科
- 遺伝学
背景:
- 家族性高リスク (FHR) は統合失調症 (SZ) と双極性障害 (BP) の最も強い予測因子です.
- FHRの子どもたちは 脆弱性の早期脳マーカーを 特定するユニークな機会を 提供しています
- 性別特有の脳の発達軌跡は,FHR集団における性差の調査を必要とします.
研究 の 目的:
- FHR-SZまたはFHR-BPで11~12歳の子供たちの脳形状の性別別群差を調べる.
- SZとBPの潜在的な性特異性エンドフェノタイプのマーカーを特定する.
- 神経発達に関する精神医学の研究における 性に関する検討の重要性を強調する.
主な方法:
- 278人の子供を含む: 101人のFHR-SZ,64人のFHR-BP,および113人の人口ベースの対照群 (PBC).
- 構造MRIスキャンは3Tスキャナーで取得しました.
- FreeSurferを使って脳容量,皮質容量,表面積,皮質厚さを抽出しました.
主要な成果:
- 大脳,皮質,頭蓋内体積,表面積において,グループ別で有意な相互作用が認められた.
- FHR-SZの男性では,PBCの男性と比較して,脳,皮質,頭蓋内部の体積と表面積が小さかった.
- FHR-BPの女性では,PBCの女性よりも大きな脳と皮質の体積を示した.
結論:
- FHR-SZとFHR-BPの子供たちは 性別特有の形状学的な脳の違いを示しています
- これらの差異は,性別特有のエンドフェノタイプのリスクマーカーを表す可能性があります.
- 神経解剖学的変化とその予測的価値を追跡するために,将来の縦断研究が必要です.
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