関連する実験動画

Updated: Sep 10, 2025

Rapid Isolation of the Mitoribosome from HEK Cells
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Rapid Isolation of the Mitoribosome from HEK Cells

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ミトコンドリアの機能が リボソーム関連疾患の核心にあるのでしょうか?

Qiuxia Zhao1, Elif Sarinay Cenik1

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.

Trends in cell biology
|August 27, 2025
PubMed
まとめ

ダイヤモンド・ブラックファン貧血のようなリボソモパシーは タンパク質合成の欠陥だけでなく エネルギー代謝の障害から生じます この発見は 代謝経路を標的とするのが 新しい治療戦略である可能性を示唆しています

キーワード:
ミトコンドリア機能ミトコンドリオパシーリボソーム生物生成リボソモパシー

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Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
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ATP Synthase: Mechanism

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Mitochondrial Precursor Proteins

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Porin Insertion in the Outer Mitochondrial Membrane

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