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Updated: Sep 10, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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アップストリーム・オープン・リーディング・フレーム・トランスレーションは,ミトーシス的に停止した癌細胞における免疫性ペプチドのプレゼンテーションを強化する

Alexander Kowar1,2, Jonas P Becker3,4, Rossella Del Pizzo1,2

  • 1Translational Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Nature communications
|August 27, 2025
PubMed
まとめ

癌細胞は 特定の遺伝子領域の翻訳を強化し 免疫細胞の標的を作り出すことで ミトーシスを利用します これらの上流のオープン・リーディングフレーム (uORF) をミトーシス阻害剤で標的化することで,がんの免疫療法を改善することができます.

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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