ロシアにおけるアルコールの摂取と動脈動脈硬化との関連
Nikita A Mitkin1,2, Andrew N Ryabikov3,4, Olga A Mirolyubova5
1Department of Community Medicine, UiT The Arctic University of Norway, N- 9037, Tromsø, Norway. nikita.a.mitkin@uit.no.
Scientific reports
|August 27, 2025
まとめ
激しいアルコール摂取は 頸動脈の壁に直接影響を及ぼし 動脈硬化症を増加させます 危険な飲酒は高血圧による動脈硬化と関連しているが,適度な飲酒または全く飲酒しない状態は異なる関連性を示している.
科学分野:
- 心血管医学
- 公衆衛生
- 依存症 研究
背景:
- アルコール摂取と動脈動脈硬化症の関連性は議論されている.
- これらの関連性を理解することは 心血管の健康に不可欠です
- 過去の研究では 矛盾する結果が出た.
研究 の 目的:
- アルコール摂取量の変動と 頸動脈動脈硬化症のマーカーの関係を調べる
- アルコールによる直接的効果と,代謝条件によって媒介される間接的効果を区別する.
主な方法:
- ロシアのアルハンゲルスクで2357人の一般患者と272人の麻薬患者 (35歳~69歳) を対象とした横断的な研究.
- インティマ・メディアの厚さ (CIMT),プラークスコア,狭窄 (≥50%) によって評価される動脈動脈硬化症.
- 社会人口学的および代謝不良の要因 (肥満,脂質不全,高血圧,糖尿病,炎症) に調整された量子的,線形的,およびロジスティック回帰.
主要な成果:
- 薬物療法の患者は,代謝状態に関係なく,CIMT,プラークスコア,および狭窄症の確率が,問題のない患者と比較して,著しく高かった.
- 危険な飲酒はCIMTとプラークのスコアが高かったが,高血圧の調整でこれらの効果は有意ではなかった.
- 有害な飲酒は,無問題な飲酒と比較して,動脈硬化マーカーの有意な違いを示さなかった.
- 飲まないとCIMTとプラークのスコアが高くなった.
結論:
- 慢性的な重度のアルコール摂取 (麻酔科の患者) は,大動脈動脈硬化を直接促進するようです.
- 危険な飲酒と動脈硬化症の関連は 高血圧によって引き起こされる可能性が高い.
- アルコール摂取と血管の健康との複雑な関係を明らかにするためにさらなる研究が必要である.
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