関連する実験動画

Updated: Sep 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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PROTACにおけるMDM2の二重機能は,標的型タンパク質分解の領域を拡大する

Junyi Zhao1, Hongzhen Chen1, Chao Liang2,3

  • 1Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.

Biomarker research
|August 27, 2025
PubMed
まとめ

Proteolysis-targeting chimeras (PROTACs) は,標的タンパク質の分解のためにマウスダブル分2 (MDM2) を利用する. 多様な疾患に対するMDM2の先進的な治療戦略をターゲットにしたり,活用したりする最適化されたPROTAC設計です.

キーワード:
ブリッジド PROTACホモ・プロタックMDM2 についてプロタックTPD について

さらに関連する動画

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes07:22

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

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