サルコペニ性肥満患者の代謝機能障害に関連するステアトス性肝疾患の流行とリスク: システマティック・レビューとメタ解析
Peng Wang1, Xiaohui Liu1, Xiaofei Du1
1The Third Unit, Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, P. R. China.
Nutrition & metabolism
|August 27, 2025
まとめ
サルコペニ性肥満 (SO) は,代謝機能不全に関連した脂肪性肝疾患 (MASLD) のリスクを有意に増加させ,SO患者の63. 4%が影響を受ける. SOはMASLDに関連した線維症を加速し,標的のスクリーニングと介入の必要性を強調しています.
科学分野:
- ヘパトロジー
- 代謝 疾患
- 高齢者医療
背景:
- サルコペニアと肥満 (サルコペニック肥満,SO) は,代謝機能不全に関連した脂肪性肝疾患 (MASLD) の進行の主要な要因です.
- このメタ解析では,SO患者におけるMASLDの罹患率とリスクを体系的に評価しています.
研究 の 目的:
- サルコペニ性肥満患者のMASLDの流行を決定する.
- サルコペニック肥満とMASLDの発症リスクとの関連性を評価する.
- MASLDに関連する線維症の進行に対するサルコペニック肥満の影響を評価する.
主な方法:
- 2025年3月までの主要なデータベース (PubMed,Cochrane,EMBASE,Web of Science,SCOPUS) で,包括的な文献検索が行われました.
- 参加した研究は,確率比 (OR) と95%信頼区間 (CI) を計算するランダム効果モデルを使用してメタ分析された.
- ヘテロゲニティはコクランのQテストとI2統計を用いて評価され,出版バイアスはフンネルグラフとエッガーのテストを用いて評価された.
主要な成果:
- 35,373人の患者を対象とした13件の研究では,SO患者の63. 4%がMASLDであることを明らかにした.
- SOはMASLDのリスクを大幅に増加させる (OR=4. 45,95%CI:2. 57- 7. 72).
- SO患者では,MASLDに関連する線維症のリスクが2. 34倍高い (OR=2. 34,95%CI:1. 78- 3.08).
結論:
- サルコペニックな肥満は,MASLDと加速した線維症の高い罹患率と強く関連しています.
- SOを持つ人はMASLDのリスクの高い集団であり,標的のスクリーニングと介入が必要である.
- 標準化された定義と多様な集団によるさらなる高品質な研究が必要である.
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