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Updated: Apr 17, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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臨床的および分子的差異は,高腫瘍変異負荷を有するマイクロ衛星安定固体腫瘍における免疫チェックポイント阻害剤に対する異なる反応を示唆する

Imran Nizamuddin1, Tarik Demir2, Katrina Dobinda3

  • 1Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Cancers
|August 28, 2025
PubMed
まとめ

進行した固体腫瘍における免疫チェックポイント阻害剤 (ICI) への反応の予測要因が特定されました. 肝臓転移のない患者とTERT変異の患者はよりよい結果を示したが,MYC経路とMLL2変異の患者はより悪い反応を示した.

キーワード:
遺伝子変異免疫チェックポイント阻害剤肝臓転移予測バイオマーカー固体腫瘍腫瘍変異負荷

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