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Updated: Sep 10, 2025

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
07:33

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

15.6K

TRPM2駆動のシグナリングサイクルは,心血管および代謝疾患における異常な臓器間クロストークをオーケストラする

Maali AlAhmad1, Esra Elhashmi Shitaw2, Asipu Sivaprasadarao2

  • 1Department of Biological Sciences, College of Science, Kuwait University, Alshadadiya, P.O. Box 5969, Safat 130602, Kuwait.

Biomolecules
|August 28, 2025
PubMed
まとめ

酸化ストレスはTRPM2経由で心血管疾患と代謝疾患を引き起こし,反応性酸素種 (ROS) を増幅し,細胞損傷を引き起こす. このTRPM2チャネルサイクルは,リゾソーム,ミトコンドリア,および核を含み,新しい治療標的を提供しています.

キーワード:
NOX2 についてPARP についてTRPM2 について老化についてカルシウム心血管疾患臓器間のコミュニケーションリソソーム代謝疾患メタボリックシンドロームミトコンドリア酸化ストレス反応性酸素種亜鉛

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