亜鉛グリシネートは,肉鶏のネクロティック腸炎の感染を緩和する
Theros T Ng1, Brandi A Sparling1, Ramesh K Selvaraj2
1College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766, USA.
Animals : an open access journal from MDPI
|August 28, 2025
まとめ
亜鉛グリシネート (ZG) 補給により鶏の成長が改善され,死腸炎 (NE) の重症度が低下しました. 鶏の飼料に最適なZGレベルは,鳥の健康を改善し,死亡率を低下させます.
科学分野:
- 鶏の栄養と免疫学
- 動物病理学と疾病管理
- 家畜における胃腸の健康
背景:
- 死腸炎 (NE) は家禽の健康と経済的生存に重大な脅威をもたらす.
- 亜鉛のような特定の栄養素が NEを軽減する役割を理解することは極めて重要です.
- 亜鉛グリシネート (ZG) は,鶏の健康を改善するための潜在的な栄養補助食品です.
研究 の 目的:
- 鶏の死腸炎 (NE) の予防と治療における亜鉛グリシネート (ZG) の有効性を評価する.
- 成長のパフォーマンスを改善し,NEに関連する病理を減らすために最適なZG補給レベルを決定する.
- クロストリジウム・ペルフリンゲンズに対する腸内細胞の生存能力に対する亜鉛のインビトロ効果を調査する.
主な方法:
- 異なるZG用量 (40-160 mg/kg) で補給された brojler chickensの2つのin vivo実験.
- クロストリジウム・ペルフリンゲンズに挑戦されたHD-11腸内細胞に対する亜鉛の効果を評価する1つのインビトロ実験.
- 測定には,体重増加 (BWG),飼料変換比 (FCR),病変スコア,死亡率,免疫遺伝子発現 (IFN-γ,SOD1) が含まれていた.
主要な成果:
- 120mg/kgのZGサプリメントは,BWGを著しく改善し,NE病変を減少させた.
- 死亡率はZGの80 mg/ kgおよび120 mg/ kgで低下した.
- In vitroでは,亜鉛はC. perfringensの挑戦下で腸の細胞活性を高め,細胞毒性を低下させた.
- ZGによって免疫反応が調節され,IFN-γが増加し,Zn/ Cu SOD1の発現が減少した.
結論:
- 亜鉛グリシネート (ZG) はニワトリの死腸炎を緩和するのに有効です.
- 鶏の最適な性能と病気の制御のために,食事中のZGレベル120 mg/kgが推奨されています.
- 鶏肉における亜鉛の免疫調節効果に関するさらなる研究が必要である.
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