病院環境におけるヴァンコミシン耐性およびヴァンコミシン変性腸球の監視と特徴づけ

Claudia Rotondo¹, Valentina Antonelli¹, Alberto Rossi¹

¹Microbiology and Biobank Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, 00149 Rome, Italy.

Antibiotics (Basel, Switzerland)

|August 28, 2025

まとめ

病院ではバンコミシン耐性腸内球菌 (VRE) とバンコミシン変性腸内球菌 (VVE) が多く見られます. この研究は,これらの耐性菌株と戦うために,強化された監視と感染制御の必要性を強調しています.

科学分野:

微生物学
感染症
ゲノミクス

背景:

E. faecalis と E. faecium を含む腸内細菌は,重度の病院感染を引き起こす.
VREとVVEの増加は抗生物質耐性による大きな課題です

研究の目的:

入院患者におけるVREとVVEのコロニー化率を評価する.
VRE/VVE株の遺伝的多様性と伝播を調査する.

主な方法:

160人の入院患者を対象に点検調査を行いました.
分子分析と培養を用いた直腸スランプ分析.
遺伝子多様性のための全ゲノムシーケンシング (WGS) とcgMLST

主要な成果:

サンプルの33.7%がvanA/vanB遺伝子の陽性でした.
VRE (74. 5%) とVVE (25. 5%) が確認され,主にE. faeciumでした.
7つのE. faeciumクラスターが特定され,ST80が最も流行し,伝播が観察されました.

結論:

VREとVVEの株は有意な毒性と耐性を表している.
VVEは検知不足の可能性があるため,注意深く監視する必要があります.
効果的な感染制御と分子監視は予防に不可欠です.

キーワード:

抗菌剤耐性エントロコーキ病院の監視バンコミシン耐性バンコミシン変数全ゲノムシーケンシング

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