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Updated: Sep 10, 2025

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Metagenomic Analysis of Silage
Published on: January 13, 2017
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牛の生乳は,バンコミシン耐性腸菌 (VRE) のヒトへの感染の潜在的な危険性を有していますか?
Elisa Massella1, Simone Russo1, Anita Filippi1
1Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Strada Faggiola 1, Gariga di Podenzano, 29027 Piacenza, Italy.
Antibiotics (Basel, Switzerland)
|August 28, 2025
まとめ
牛乳にはバンコミシン抵抗性遺伝子 (vanC) が多く含まれているが,臨床的に重要なバンAまたはバンB遺伝子は含まれていない. これは,原牛乳がVANCエンテロコックスの拡散に寄与し,ヒトへの感染の潜在的なリスクをもたらすことを示唆しています.
科学分野:
- 微生物学
- 流行病学について
- 食品の安全性
背景:
- ヴァンコミシン耐性腸内細菌 (VRE) は,重要な病院内病原体である.
- 食品を生産する動物や製品は 潜在的VRE感染経路です
- VREの伝播における牛乳の役割は調査が必要である.
研究 の 目的:
- VREが人間に感染する際の牛乳の疫学的な役割を調査する.
- バンコマイシン耐性遺伝子の検査のために
- マスティトゲン性腸球菌を特徴づけ,その抗菌剤耐性プロフィールを評価する.
主な方法:
- マルチプレックスPCRでバンの遺伝子を検出した.
- 牛乳のサンプルから採取した乳がん性腸菌は,抗菌感受性検査を受けた.
- バンコマイシンに敏感でない株で全ゲノム配列解析を行った.
主要な成果:
- バルクミルクサンプルの29. 14%でvanC遺伝子が検出され,vanC1 (19. 88%) とvanC2/3 (5. 56%) が特定されました.
- 臨床的に有意なvanAとvanB遺伝子は検出されなかった.
- 163のマスティトゲン性エンテロコックスの株が分離され,E. faeciumとE. faecalisが最も一般的であり,65. 03%が多剤耐性を示した.
- バンコミシンに敏感でない2つの菌株 (vanC2/3 E. casseliflavusとvanC1 E. gallinarum) を特定し,全ゲノム配列を解析した.
結論:
- 牛の生乳は,バンAまたはバンB VREの重要な源である可能性は低い.
- 生牛乳は,VanCの腸球の拡散に寄与する可能性があります.
- 生ミルクからのVANCエンテロコックは,ますますヒトの感染症に関連しています.
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