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Updated: Sep 10, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

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ヒトの疾患におけるグリコミクスとバイオマーカーの発見におけるその新興の役割

Sherifdeen Onigbinde1, Moyinoluwa Adeniyi1, Oluwatosin Daramola1

  • 1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.

Biomedicines
|August 28, 2025
PubMed
まとめ

糖分を分子に添加するプロセスである 糖分を分子に添加するプロセスである 糖分を分子に添加するプロセスである 糖分を分子に添加するプロセスである 異常なグリコシレーションは癌,神経変性,感染症と関連しており,新たな治療目標を提供している.

キーワード:
癌のバイオマーカーグライカンの生物合成グライコエンジニアリンググライコミックグライコシレーション免疫調節神経変性疾患トランスレーション・グリコバイオロジー

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Glycan Node Analysis: A Bottom-up Approach to Glycomics11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

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Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay09:13

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

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関連する概念動画

Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
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Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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