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Updated: Sep 10, 2025

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
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チオエスター経由で糖から酸: 計算による研究

Jeremy Kua1, Jonathan D Karin1

  • 1Department of Chemistry & Biochemistry, University of San Diego, San Diego, CA 92110, USA.

Life (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

糖はチオールアルデヒド反応によって酵素なしでカルボキシル酸に変換できる. 熱力学的には好ましいが,反応速度は水または硫化水素の除去によって制限され,アルファ二炭化物はより効率的な触媒であることを示唆している.

キーワード:
生命の起源プレビオティック化学プロトメタボリズムチオエステル

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