関連する実験動画

Updated: Sep 10, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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新しい小分子GRP94調節器はPCSK9の分泌を増やし,LDLRの分解を促進する

Wenjing Yan1, Yongwang Zhong1, Shengyun Fang1,2

  • 1Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Life (Basel, Switzerland)
|August 28, 2025
PubMed
まとめ

新しい化合物であるNSC637153 (cp153) は,エンドプラズマ網膜チャペロンGRP94を選択的に標的とする. この発見は,タンパク質の恒常性を研究し,GRP94機能障害に関連する疾患の治療法を開発するためのツールを提供します.

キーワード:
ERに関連した分解 (ERAD)GRP94 についてPCSK9-LDLR についてタンパク質の品質管理

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