機能性神経疾患のサブタイプにおける併発症:包括的な物語の合成
Ioannis Mavroudis1,2,3,4, Katerina Franekova2, Foivos Petridis3
1Department of Neuroscience, Leeds Teaching Hospital, NHS Trust, Leeds LS17 7HY, UK.
Life (Basel, Switzerland)
|August 28, 2025
まとめ
機能神経障害 (FND) には様々な症状が伴う. 併発性精神病や医学的な状態は一般的であり,FCD,FMD,PNESなどのサブタイプにおけるFNDの発現と治療に影響を与えます.
科学分野:
- 神経科学
- 精神科
- 臨床心理学
背景:
- 機能神経疾患 (FND) は,構造的な神経疾患によって説明されない多様な症状 (運動,認知,発作のような) を表します.
- 併発性精神疾患と体疾患は,FNDの臨床経過,診断の複雑さ,治療結果に大きな影響を及ぼします.
研究 の 目的:
- 主要なFNDサブタイプである機能的認知障害 (FCD),機能的運動障害 (FMD),および精神性非発作 (PNES) の精神疾患および医学的な併発症を体系的に調査する.
- FNDの併発性におけるサブタイプ特有のパターンと共通の脆弱性を特定する.
主な方法:
- 体系的原則とPRISMAのガイドラインを用いて文献レビューを行った.
- FCD,FMD,PNES,PPPD,および一般的なFNDの共同疾患に関する基礎的および現代的な研究が含まれています.
- FNDのサブタイプと併発性タイプ (精神病または医学/体質) による抽出データ
主要な成果:
- すべてのFNDサブタイプで高い精神疾患 (うつ,不安,PTSD,解離) が観察されました.
- FCDは内在的な症状に関連し, FMDはトラウマと感情的不調に関連し,PNESは精神的負担が最も高いことを示しました.
- 流行している体内併発症 (線維筋痛,慢性疼痛,IBS,疲労) は,バイオサイコ社会的メカニズムが重なり合っていることを示唆している.
結論:
- 併発性精神疾患と医学的な状態は,FNDの理解と管理に不可欠です.
- サブタイプ特有のパターンは,個別化された診断と治療戦略を必要とします.
- 共有された生体心理的メカニズムは,FNDのスペクトルの統合ケアモデルをサポートします.
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