Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers01:27

Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers

970
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
970
Adrenergic Antagonists: ɑ and β-Receptor Blockers01:31

Adrenergic Antagonists: ɑ and β-Receptor Blockers

597
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
597
Antihypertensive Drugs: Types of β-Blockers01:28

Antihypertensive Drugs: Types of β-Blockers

863
β receptors are classified into three subclasses: β1, β2, and β3. β1 receptors are primarily located in the heart and kidneys. When they get activated, they increase heart rate, contractility, and renin release. This process enhances blood pressure and aids in stress management. In contrast, β2 receptors are situated mainly in the lungs, blood vessels, and skeletal muscles. Upon activation, they trigger smooth muscle relaxation, causing bronchodilation and...
863
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

434
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
434
Antihypertensive Drugs: Action of β1 Blockers01:17

Antihypertensive Drugs: Action of β1 Blockers

609
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
609
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

911
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
911
このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 心血管医学と血液学
  9. 心臓病 (心血管疾患を含む)
  11. ベータブロッカーの使用と関節整形手術のリスク: 電子医療記録による遡及的研究

ベータブロッカーの使用と関節整形手術のリスク: 電子医療記録による遡及的研究

Ping-Hao Chiang1, Yang-Chi Lin2, Jing-Yang Huang3

  • 1Department of Medical Education, Chiayi Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.

Life (Basel, Switzerland)
|August 28, 2025

関連する実験動画

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.1K
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

3.0K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

370

PubMed で要約を見る

まとめ
この要約は機械生成です。

ベータブロッカー (BB) の使用は,股関節関節炎の患者における全身関節整形手術のリスクの増加と関連しています. この関連性や特定のBBサブタイプを理解するには,さらなる研究が必要です.

科学分野:

  • 整形 術
  • 薬理学について
  • 流行病学

背景:

  • 股関節関節炎は手術を必要とする一般的な状態です.
  • ベータブロッカー (BB) は,心血管および他の潜在的な効果を持つ広く処方される薬です.
  • 股関節炎 (OA) の患者におけるBB使用と全関節整形手術 (THA) のリスクの関係が完全に理解されていません.

研究 の 目的:

  • 前回のベータブロッカー (BB) 使用と3年間の全関節整形手術 (THA) のリスクとの関連を調査する.
  • ベータ阻害剤の異なるサブタイプにおけるTHAのリスクを比較する.

主な方法:

  • トリネットXのデータベースを使って 股関節炎の患者を特定した
  • BB使用者と非使用者のグループに分け,BB使用者を処方箋と再注入経歴で定義した.
  • 混同因子に対するコントロールと一致する従業員の傾向スコアと,THAの3年間のリスクを計算した.

主要な成果:

  • 研究には313,430人の患者が参加し,マッチングの結果,23,096人が各コホートに留まった (BB使用者 vs 非使用者).
  • ベータブロッカー (BB) の使用は,THA (HR = 1. 494) を受けるリスクが著しく高かった.
  • BBサブタイプの中で,アルファ-BBは,非-BBコホートと比較してTHAリスクが最も高い割合を示した (HR=1. 639).
キーワード:
ベータブロッカーコホート研究非選択性ベータブロッカー

関連する実験動画

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

3.1K
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

3.0K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

370

結論:

  • 発見は,ベータブロッカー (BB) の使用と,骨関節炎 (OA) 患者における関節整形手術のリスクの増加との潜在的な関連を示唆しています.
  • アルファ-BBsの特定のサブタイプは,より高いリスクを伴う可能性があります.
  • 根底にあるメカニズムのさらなる調査は必要ですが,臨床実務の即時変更は推奨されません.
腰の関節炎 腰の関節炎
セレクティブベータブロッカー
トータル ヒップ 関節整形