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Updated: Sep 10, 2025

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胃がん治療におけるATR-CHK1軸阻害剤

Mateusz Kciuk1, Renata Gruszka1, Marta Aleksandrowicz2

  • 1Department of Molecular Biotechnology and Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

ATR-CHK1阻害剤は,DNA損傷反応経路を標的として,胃がんの治療に有望であることが示されています. このアプローチは,特に他の治療法と組み合わせると,病気が進行した患者に新しい治療戦略を提供します.

キーワード:
ARID1A 損失ATRCHK1阻害剤DNA 損傷反応TP53変異バイオマーカーによる治療胃がん免疫調節複製ストレス合成による死亡率トリートメント耐性

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