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Updated: Sep 10, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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インポートインα3は核定位信号のキラリティに耐性がある

Felipe Hornos1, Bruno Rizzuti2,3, José L Neira1,3

  • 1IDIBE, Instituto de investigación, Desarrollo e Innovación en Biotecnologia Sanitaria de Elche, Universidad Miguel Hernández, 03202 Elche, Alicante, Spain.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

核局所信号 (NLS) の立体化学は,インポートリンタンパク質への結合に影響を与えない. この発見は,真核細胞における核タンパク質の輸入を理解するために極めて重要です.

キーワード:
D-エナントイオマー拘束力のあるカロリメトリ乱れたペプチド光分子シミュレーション核の位置づけ信号

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Nuclear Localization Signals and Import

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Translocation of Proteins into the Mitochondria

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Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
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Nuclear Protein Sorting

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Mitochondrial Precursor Proteins

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Directionality of Nuclear Transport

Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of  Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...
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