関連する実験動画

Updated: Sep 10, 2025

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines
10:16

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines

Published on: October 8, 2015

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BRAF V600E変異は,MAPK経路遺伝子の発現に変化する腫瘍特異的な影響を及ぼし,患者の結果に影響を与える可能性があります

Sourat Darabi1, Phillip Stafford1,2,3, David R Braxton1

  • 1Hoag Family Cancer Institute, Newport Beach, CA 92663, USA.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

BRAF阻害剤はメラノーマには有効ですが,甲状腺癌には有効ではありません. この研究では,BRAF変異を有するメラノーマではミトゲン活性化タンパク質キナーゼ (MAPK) 経路の活性化が増加したが,甲状腺がんではそうではなかった.

キーワード:
BRAF変異RNAの発現メラノーマ甲状腺がん全エクソームシーケンシングトランスクリプトーム全体のシーケンシング

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