関連する実験動画

Updated: Sep 10, 2025

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
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Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

Published on: April 22, 2022

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FEN1によるプライム編集は,呼吸道基底細胞のCFTR遺伝子のF508del変異編集を改善する

Olga V Volodina1, Anna G Demchenko1, Arina A Anuchina1,2

  • 1Laboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

胞性線維症を引き起こす CFTR 変異を修正する見込みがある. 改造されたPEmaxシステム,4-FENは患者の細胞の編集効率を向上させましたが,ATが豊富な領域は依然として困難です.

キーワード:
EXO1 についてFEN1 について胞性線維症遺伝子編集遺伝子療法プライム編集

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