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Updated: Sep 10, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

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Published on: June 9, 2017

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バイアスされたリガンドとGRKサブタイプによるAT1Rの明確なリン酸化パターン

Zisu Zhang1, Chuyi Liu2, Jinda Gong1

  • 1The Second Affiliated Hospital of Zhejiang University School of Medicine, Research Center for Clinical Pharmacy, Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

International journal of molecular sciences
|August 28, 2025
PubMed
まとめ

異なるアゴニストとGPCRキナーゼ (GRKs) は,独特のアンジオテンシンII型1受容体 (AT1R) リン酸化パターンを生成し,β-アレスティンの徴用に影響を与えます. これらのバーコードの理解は AT1Rの治療開発に偏りがあります

キーワード:
AT1R についてグルジアバイアスしたリガンドリン酸化β-アレスティン

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